https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Body mass index and incident hospitalisation for cardiovascular disease in 158 546 participants from the 45 and Up Study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21379 -2, including 3096 for ischaemic heart disease (IHD), 1373 for stroke, 411 for peripheral vascular disease (PVD) and 320 for heart failure. The adjusted HR of hospitalisation for all CVD diagnoses combined increased significantly with increasing BMI (P(trend) <0.0001)). The HR of IHD hospitalisation increased by 23% (95% confidence interval (95% CI): 18-27%) per 5 kg m-2 increase in BMI (compared to BMI 20.0-22.49 kg m-2, HR (95% CI) for BMI categories were: 22.5-24.99=1.25 (1.08-1.44); 25-27.49=1.43 (1.24-1.65); 27.5-29.99=1.64 (1.42-1.90); 30-32.49=1.63 (1.39-1.91) and 32.5-50=2.10 (1.79-2.45)). The risk of hospitalisation for heart failure showed a significant, but nonlinear, increase with increasing BMI. No significant increase was seen with above-normal BMI for stroke or PVD. For other specific classifications of CVD, HRs of hospitalisation increased significantly with increasing BMI for: hypertension; angina; acute myocardial infarction; chronic IHD; pulmonary embolism; non-rheumatic aortic valve disorders; atrioventricular and left bundle-branch block; atrial fibrillation and flutter; aortic aneurysm; and phlebitis and thrombophlebitis. Conclusion: The risk of hospitalisation for a wide range of CVD subtypes increases with relatively fine increments in BMI. Obesity prevention strategies are likely to benefit from focusing on bringing down the mean BMI at the population level, in addition to targeting those with a high BMI.]]> Wed 11 Apr 2018 14:09:31 AEST ]]> Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20947 50, p=4.02E-06), which may have clinical/biological implications.]]> Sat 24 Mar 2018 08:06:08 AEDT ]]> Histone deacetylase 5 blocks neuroblastoma cell differentiation by interacting with N-Myc https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18778 Sat 24 Mar 2018 07:51:10 AEDT ]]> Thermal characterization of chemically reduced electrolytic manganese dioxide https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:342 Sat 24 Mar 2018 07:42:28 AEDT ]]> DSC characterisation of chemically reduced electrolytic manganese dioxide https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3431 Sat 24 Mar 2018 07:20:25 AEDT ]]>